A boutique beer and wine store will soon open in Highlandtown, continuing the revival of the once blue-collar, shot-and-a-beer part of town.

Off the Rox will occupy an 800-square-foot street-level retail space in the new Highland Haus apartment building on the former Haussner’s restaurant site at 3244 Eastern Ave.

“We want to have high-end beer and wine and focus on local beers and wines — a little bit of everything,” said Jeryl Cole, who will own the store with his wife, Tyrekia.

Cole, 27,…